A randomized controlled trial of oxygen therapy in acute myocardial infarction Air Verses Oxygen In myocarDial infarction study (AVOID Study)

Background The role of routine supplemental oxygen for patients with uncomplicated acute myocardial infarction (AMI) has recently been questioned. There is conflicting data on the possible effects of hyperoxia on ischemic myocardium. The few clinical trials examining the role of oxygen in AMI were p...

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Bibliographic Details
Published in:The American heart journal 2012-03, Vol.163 (3), p.339-345.e1
Main Authors: Stub, Dion, MBBS, Smith, Karen, BSc(Hons) PhD, Bernard, Stephen, MBBS MD, Bray, Janet E., RN, PhD, Stephenson, Michael, RN, BHlthSc, Grad, Dip (MICA), Cameron, Peter, MBBS, MD, Meredith, Ian, BSc, MBBS, PhD, Kaye, David M., MBBS, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Air
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Coronary heart disease
Coronary vessels
Electrocardiography
Emergency Medical Services - methods
Follow-Up Studies
Heart
Heart attacks
Humans
Medical sciences
Mortality
Myocardial Infarction - diagnosis
Myocardial Infarction - therapy
Myocarditis. Cardiomyopathies
Oxygen
Oxygen Inhalation Therapy - methods
Prospective Studies
Studies
Treatment Outcome
Victoria
Young Adult
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Summary:Background The role of routine supplemental oxygen for patients with uncomplicated acute myocardial infarction (AMI) has recently been questioned. There is conflicting data on the possible effects of hyperoxia on ischemic myocardium. The few clinical trials examining the role of oxygen in AMI were performed prior to the modern approach of emergent reperfusion and advanced medical management. Methods Air Verses Oxygen In myocarDial infarction study (AVOID Study) is a prospective, multi-centre, randomized, controlled trial conducted by Ambulance Victoria and participating metropolitan Melbourne hospitals with primary percutaneous coronary intervention capabilities. The purpose of the study is to determine whether withholding routine supplemental oxygen therapy in patients with acute ST-elevation myocardial infarction but without hypoxia prior to reperfusion decreases myocardial infarct size. AVOID will enroll 490 patients, >18 years of age with acute ST-elevation myocardial infarction of less than 12 hours duration. Conclusions There is an urgent need for clinical trials examining the role of oxygen in AMI. AVOID will seek to clarify this important issue. Results from this study may have widespread implications on the treatment of AMI and the use of oxygen in both the pre-hospital and hospital settings.
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2011.11.011