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POODLE-I: Disordered Region Prediction by Integrating POODLE Series and Structural Information Predictors Based on a Workflow Approach
Under physiological conditions, many proteins that include a region lacking well-defined three-dimensional structures have been identified, especially in eukaryotes. These regions often play an important biological cellular role, although they cannot form a stable structure. Therefore, they are biol...
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Published in: | In silico biology 2010, Vol.10 (3-4), p.185-191 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Under physiological conditions, many proteins that include a region
lacking well-defined three-dimensional structures have been identified,
especially in eukaryotes. These regions often play an important biological
cellular role, although they cannot form a stable structure. Therefore, they
are biologically remarkable phenomena. From an industrial perspective, they can
provide useful information for determining three-dimensional structures or
designing drugs. For these reasons, disordered regions have attracted a great
deal of attention in recent years. Their accurate prediction is therefore
anticipated to provide annotations that are useful for wide range of
applications.
POODLE-I (where "I" stands for integration) is a web-based
disordered region prediction system. POODLE-I integrates prediction results
obtained from three kinds of disordered region predictors (POODLEs) developed
from the viewpoint that the characteristics of disordered regions change
according to their length. Furthermore, POODLE-I combines that information with
predicted structural information by application of a workflow approach. When
compared with server teams that showed best performance in CASP8, POODLE-I
ranked among the top and exhibited the highest performance in predicting
unfolded proteins.
POODLE-I is an efficient tool for detecting disordered regions in
proteins solely from the amino acid sequence. The application is freely
available at http://mbs.cbrc.jp/poodle/poodle-i.html. |
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ISSN: | 1386-6338 1434-3207 |
DOI: | 10.3233/ISB-2010-0426 |