Neural substrates for serial reaction time tasks in pigeons

• Published in: Behavioural brain research 2012-04, Vol.230 (1), p.132-143
• Main Authors: Helduser, Sascha, Güntürkün, Onur
• Format: Article
• Language: English
• Subjects: Anesthetics, Local - pharmacology; Animals; Brain - anatomy & histology; Brain - drug effects; Brain - physiology; Brain Mapping; Choice Behavior - drug effects; Choice Behavior - physiology; Columbidae; Conditioning, Operant - drug effects; Motor sequence; Neural Pathways - drug effects; Neural Pathways - physiology; Reaction Time - drug effects; Reaction Time - physiology; Sequence execution; Serial Learning - drug effects; Serial Learning - physiology; Serial reaction time task; Song system; Tetrodotoxin; Tetrodotoxin - pharmacology
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2012.02.013

► We identified neural structures that underlie sequence execution in pigeons. ► Neural circuits for sequence behavior in pigeons resemble the song system. ► A serial reaction time task was applied in combination with TTX inactivation. ► Inactivation of either of two brain areas yielded sequence specific errors. Most behavior is composed of action sequences. Pigeons were often used as a model to study sequence learning and execution. Yet, virtually nothing is known about the neural structures underlying sequential behavior in pigeons. We therefore applied a serial reaction time task (SRTT) that is commonly used to investigate sequential behavior. During task performance either the nidopallium caudolaterale (NCL) or the nidopallium intermedium medialis pars laterale (NIMl) was transiently inactivated with tetrodotoxin (TTX). Since prefrontal structures play a role in sequence acquisition and performance in mammals and since the NCL is functionally analogous to the prefrontal cortex, NCL was chosen a possibly critical structure of our study. The NIMl is equivalent by hodology and topology to the song nucleus LMAN. Since LMAN plays a key role in song learning and since song consists of learned vocalizatory sequences, we hypothesized that NIMl could also be a candidate for sequence performance in a non-songbird. Moreover, TTX injections into the entopallium were performed as a control. Indeed, inactivation of both the NCL and the NIMl resulted in an increase of sequence specific errors. Hence, we could identify components of neural systems in the pigeon that underlie sequence execution.