Cervical necrotizing fasciitis: 8-years’ experience of microbiology

Cervical necrotizing fasciitis (CNF) is a life-threatening complication of pharyngeal or dental infections. The aim of this paper was to investigate whether dental or pharyngeal source result from different pathogen(s) in CNF and whether antibiotics, given before admission, influence the antimicrobi...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2008-08, Vol.27 (8), p.691-695
Main Authors: Fihman, V., Raskine, L., Petitpas, F., Mateo, J., Kania, R., Gravisse, J., Resche-Rigon, M., Farhat, I., Berçot, B., Payen, D., Sanson-Le Pors, M. J., Herman, P., Mebazaa, A.
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Bacteria
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Bacteroidaceae Infections - microbiology
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Clindamycin - pharmacology
Dental plaque
Drug resistance
Fasciitis, Necrotizing - microbiology
Focal Infection, Dental - microbiology
Human bacterial diseases
Humans
Infections
Infectious diseases
Internal Medicine
Medical Microbiology
Medical sciences
Microbiology
Necrotizing fasciitis
Pathogens
Patients
Penicillins - pharmacology
Pharyngeal Diseases - microbiology
Prevotella
Prevotella - drug effects
Streptococcus milleri
Streptococcus milleri Group - drug effects
Surgery
Synergistic effect
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Summary:Cervical necrotizing fasciitis (CNF) is a life-threatening complication of pharyngeal or dental infections. The aim of this paper was to investigate whether dental or pharyngeal source result from different pathogen(s) in CNF and whether antibiotics, given before admission, influence the antimicrobial resistance of pathogens. In 152 CNF patients, Streptococcus milleri group and Prevotella species were the predominant isolates, frequently copathogens, mostly in dental CNF samples. Penicillin and clindamycin resistance were observed in 39% and 37% of cases, respectively, independently of any previous antibiotic therapy. Thus, a combined aerobe–anaerobe infection may have a synergistic effect, which allows the infection to spread in cervical tissues.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-008-0491-9