Myasthenia gravis: a changing pattern of incidence

The annual incidence of myasthenia gravis (MG) ranges from 3 to 30 per 1,000,000 people. Since the mid-1980s, an increasing incidence has been reported, mainly due to late-onset MG. Whether the increase was due to population aging, improved diagnosis and case collection, or a true excess of incidenc...

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Bibliographic Details
Published in:Journal of neurology 2010-12, Vol.257 (12), p.2015-2019
Main Authors: Casetta, I., Groppo, E., De Gennaro, R., Cesnik, E., Piccolo, L., Volpato, S., Granieri, E.
Format: Article
Language:English
Subjects:
Age
Aged
Biological and medical sciences
Cohort Studies
Disease
Diseases of striated muscles. Neuromuscular diseases
Epidemiology
Female
Hospitals
Humans
Incidence
Internal medicine
Italy - epidemiology
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Myasthenia gravis
Myasthenia Gravis - diagnosis
Myasthenia Gravis - epidemiology
Neurology
Neuroradiology
Neurosciences
Older people
Original Communication
Outpatient care facilities
Patients
Thoracic surgery
Trends
Womens health
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Summary:The annual incidence of myasthenia gravis (MG) ranges from 3 to 30 per 1,000,000 people. Since the mid-1980s, an increasing incidence has been reported, mainly due to late-onset MG. Whether the increase was due to population aging, improved diagnosis and case collection, or a true excess of incidence cases is still under debate. We used a complete enumeration approach by reviewing all possible sources of case collection in the province of Ferrara, Italy, to estimate the MG incidence and its temporal trend over the study period (1985–2007). The mean annual age-adjusted incidence of MG was 18 per 1,000,000, without any significant temporal trend. The incidence rates in the period 1985–1990 were 14 both for early and late-onset MG. Thereafter, a significant increase in incidence of late-onset MG ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-010-5651-z