Bone disease and hypercalciuria in children

There have been relatively few studies of bone mass in children with idiopathic hypercalciuria (IH). When performed, bone mineral density (BMD) measurements have consistently disclosed decreased Z-scores for children with IH at the lumbar spine and, to a lesser extent, at the femoral neck. Few inves...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2010-03, Vol.25 (3), p.395-401
Main Author: Zerwekh, Joseph E.
Format: Article
Language:English
Subjects:
Bone density
Bone Density - physiology
Bone Development - physiology
Bone Diseases - complications
Bone Diseases - pathology
Bone Resorption - pathology
Bones
Child
Children
Children & youth
Density
Disease
Humans
Hypercalciuria - complications
Hypercalciuria - pathology
Medicine
Medicine & Public Health
Nephrology
Organ Size - physiology
Osteoporosis
Pediatrics
Review
Skeletal system
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There have been relatively few studies of bone mass in children with idiopathic hypercalciuria (IH). When performed, bone mineral density (BMD) measurements have consistently disclosed decreased Z-scores for children with IH at the lumbar spine and, to a lesser extent, at the femoral neck. Few investigations have delineated the nature of the mechanism(s) that may contribute to the bone loss in these children. Some studies have been consistent, showing increased bone resorption as the probable mechanism of bone loss. To date, there have been no reports regarding the assessment of biochemical markers specific for bone formation in children with IH. However, since most of the children with IH in these reports had demonstrated normal longitudinal growth, it seems less likely that there is an alteration in bone formation. The causes for increased bone resorption also are not firmly established, but genetics, dietary indiscretions, and altered cytokine production have been proposed as being contributory to the decreased BMD observed in these children with IH. Optimal bone mineral accretion during childhood and adolescence is important in attaining peak bone mass and may serve to prevent the development of osteoporosis in adulthood. Thus, a better understanding of bone loss in children with IH is warranted.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-009-1338-z