Myocardial perfusion imaging using adenosine-induced stress dual-energy computed tomography of the heart: comparison with cardiac magnetic resonance imaging and conventional coronary angiography

Objective To evaluate the feasibility and diagnostic accuracy of adenosine-stress dual-energy computed tomography (DECT) for detecting haemodynamically significant stenosis causing reversible myocardial perfusion defect (PD) compared with stress perfusion magnetic resonance imaging (SP-MRI) and conv...

Full description

Saved in:
Bibliographic Details
Published in:European radiology 2011, Vol.21 (1), p.26-35
Main Authors: Ko, Sung Min, Choi, Jin Woo, Song, Meong Gun, Shin, Je Kyoun, Chee, Hyun Kun, Chung, Hyun Woo, Kim, Dong Hun
Format: Article
Language:English
Subjects:
Adenosine
Aged
Cardiac
Coronary Angiography
Coronary Artery Disease - diagnosis
Diagnostic Radiology
Echocardiography, Stress
Female
Heart - diagnostic imaging
Humans
Imaging
Internal Medicine
Interventional Radiology
Magnetic Resonance Angiography
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Radiology
Tomography, X-Ray Computed
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To evaluate the feasibility and diagnostic accuracy of adenosine-stress dual-energy computed tomography (DECT) for detecting haemodynamically significant stenosis causing reversible myocardial perfusion defect (PD) compared with stress perfusion magnetic resonance imaging (SP-MRI) and conventional coronary angiography (CCA). Methods Fifty patients with known coronary artery disease (CAD) detected by dual-source CT (DSCT) were investigated by contrast-enhanced, stress DECT with high- and low-energy x-ray spectra settings during adenosine infusion. A colour-coded iodine map was used for evaluation of myocardial PDs compared with rest DSCT perfusion images. Reversible myocardial PDs according to the stress DECT/rest DSCT were compared with SP-MRI on a segmental basis and CCA on a vascular territorial basis. Results A total of 697 myocardial segments and 123 vascular territories of 41 patients were analysed. Three hundred one segments and 72 vascular territories in 38 patients showed reversible PDs on stress DECT. Stress DECT had 89% sensitivity, 78% specificity and 82% accuracy for detecting segments with reversible PDs seen on SP-MRI (n = 28). Compared with CCA (n = 41), stress DECT had 89% sensitivity, 76% specificity and 83% accuracy for the detection of vascular territories with reversible myocardial PDs that had haemodynamically relevant CAD. Conclusion Adenosine stress DECT can identify stress-induced myocardial PD in patients with CAD.
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-010-1897-1