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Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study

We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m2), were genotyped for four haplotype-tagged s...

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Published in:	Endocrine Journal 2012, Vol.59(3), pp.229-237
Main Authors:	Zheng, Juan, Chen, Lu-Lu, Xiao, Fangxi, Hu, Xiang, Deng, Xiulin, Li, Huiqing
Format:	Article
Language:	English
Subjects:	Adult Aged Alleles Asian Continental Ancestry Group - genetics Body Mass Index Case-Control Studies China Chinese population Female Gene Frequency Genetic association Genetic Association Studies Genetic Predisposition to Disease Genotype Haplotypes Humans Male Middle Aged Overweight Overweight - genetics Polymorphism, Single Nucleotide Single nucleotide polymorphisms SIRT1 gene Sirtuin 1 - genetics
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container_title	Endocrine Journal
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creator	Zheng, Juan Chen, Lu-Lu Xiao, Fangxi Hu, Xiang Deng, Xiulin Li, Huiqing
description	We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m2), were genotyped for four haplotype-tagged single nucleotide polymorphisms. The rs10509291AA and rs10823116GG genotypes were associated with high body mass index (BMI) > 23 Kg/m2, and the rs7894483TT genotype was associated with lower BMI (< 23 Kg/m2). The rs10509291AT genotype was associated with a modestly higher risk of being overweight, consistent with the presence of an rs10509291A being a dominant or semi-dominant allele. The ATAA (rs7894483/rs10823116) and ATAG haplotypes were associated with a higher risk of being overweight (OR: 17.11 and 5.12) compared with the AAAG haplotype (P 23 Kg/m2) and with overweight in this non-diabetic Chinese population.
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subjects	Adult Aged Alleles Asian Continental Ancestry Group - genetics Body Mass Index Case-Control Studies China Chinese population Female Gene Frequency Genetic association Genetic Association Studies Genetic Predisposition to Disease Genotype Haplotypes Humans Male Middle Aged Overweight Overweight - genetics Polymorphism, Single Nucleotide Single nucleotide polymorphisms SIRT1 gene Sirtuin 1 - genetics
title	Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study
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