Thermoanalytical investigation of olanzapine compatibility with excipients used in solid oral dosage forms

During preformulation studies of pharmaceutical solid dosage forms, thermal analysis techniques are very useful to detect physical or chemical incompatibilities between the drug and adjuvants of interest that might interfere with efficacy and safety of the final drug product. Differential scanning c...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2011-04, Vol.104 (1), p.255-260
Main Authors: Peres-Filho, Marco Júnio, Gaeti, Marilisa Pedroso Nogueira, de Oliveira, Stela Ramirez, Marreto, Ricardo Neves, Lima, Eliana Martins
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biological and medical sciences
Calorimetry
Cellulose
Chemistry
Chemistry and Materials Science
Differential scanning calorimetry
Diffraction
Dosage
Drugs
Excipients
General pharmacology
Inorganic Chemistry
Investigations
Lactose
Magnesium compounds
Magnesium stearate
Measurement Science and Instrumentation
Medical sciences
Olanzapine
Pharmaceutical technology. Pharmaceutical industry
Pharmaceuticals
Pharmacology. Drug treatments
Phosphates
Physical Chemistry
Polymer Sciences
Thermal analysis
X-rays
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Summary:During preformulation studies of pharmaceutical solid dosage forms, thermal analysis techniques are very useful to detect physical or chemical incompatibilities between the drug and adjuvants of interest that might interfere with efficacy and safety of the final drug product. Differential scanning calorimetry (DSC) and thermogravimetry (TG) are useful tools for this purpose. The aim of this study was to investigate the thermoanalytical behavior of olanzapine (OLZ) when mixed with several excipients commonly used in solid dosage forms such as microcrystalline cellulose, croscarmellose, dicalcium phosphate dihydrate (DCPD), lactose, magnesium stearate, and povidone. Following DSC and TG analyses, powder X-ray diffraction tests were carried out. Thermoanalytical methods showed evidence of interaction between OLZ and magnesium stearate, lactose, and povidone. These results can be useful during the selection of excipients for pharmaceutical formulation development.
ISSN:1388-6150
1588-2926
1572-8943
DOI:10.1007/s10973-010-1245-3