Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel

Nano-encapsulation of a poorly soluble anticancer drug was demonstrated with a sonication assisted layer-by-layer polyelectrolyte coating (SLbL). We changed the strategy of LbL-encapsulation from making microcapsules with many layers in the walls for encasing highly soluble materials to using a very...

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Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2011-01, Vol.13 (19), p.9014-9019
Main Authors: PATTEKARI, P, ZHENG, Z, ZHANG, X, LEVCHENKO, T, TORCHILIN, V, LVOV, Y
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Chemistry
Colloidal state and disperse state
Colloids - chemistry
Drugs
Ethyl alcohol
Exact sciences and technology
General and physical chemistry
Molecular Conformation
Nanocomposites
Nanomaterials
Nanostructure
Nanostructures - chemistry
Paclitaxel - chemistry
Particle Size
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Polyelectrolytes
Solubility
Surface chemistry
Surface physical chemistry
Surface Properties
Water - chemistry
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Summary:Nano-encapsulation of a poorly soluble anticancer drug was demonstrated with a sonication assisted layer-by-layer polyelectrolyte coating (SLbL). We changed the strategy of LbL-encapsulation from making microcapsules with many layers in the walls for encasing highly soluble materials to using a very thin polycation/polyanion coating on low solubility nanoparticles to provide them with good colloidal stability. SLbL encapsulation of paclitaxel resulted in stable 100-200 nm diameter colloids with a high electrical surface ξ-potential (of -45 mV) and drug content in the nanoparticles of 90 wt%. In the top-down approach, nanocolloids were prepared by rupturing a powder of paclitaxel using ultrasonication and simultaneous sequential adsorption of oppositely charged biocompatible polyelectrolytes. In the bottom-up approach paclitaxel was dissolved in organic solvent (ethanol or acetone), and drug nucleation was initiated by the addition of aqueous polyelectrolyte assisted by ultrasonication. Paclitaxel release rates from such nanocapsules were controlled by assembling multilayer shells with variable thicknesses and were in the range of 10-20 h.
ISSN:1463-9076
1463-9084
DOI:10.1039/c0cp02549f