Protective Role of Quercetin on PCBs-Induced Oxidative Stress and Apoptosis in Hippocampus of Adult Rats

Polychlorinated biphenyls (PCBs) exposure produces neurodegeneration and induces oxidative stress. Neuroprotective role of quercetin, on PCBs induced apoptosis in hippocampus has not yet been studied. The present study is focused to see whether quercetin supplementation precludes against PCBs induce...

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Bibliographic Details
Published in:Neurochemical research 2012-04, Vol.37 (4), p.708-721
Main Authors: Selvakumar, Kandaswamy, Bavithra, Senthamilselvan, Suganthi, Muralidharan, Benson, Chellakan Selvanesan, Elumalai, Perumal, Arunkumar, Ramachandran, Krishnamoorthy, Gunasekaran, Venkataraman, Prabhu, Arunakaran, Jagadeesan
Format: Article
Language:English
Subjects:
Age Factors
Animals
Antioxidants - pharmacology
Apoptosis
Apoptosis - drug effects
Apoptosis - physiology
Bax protein
BID protein
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
DNA damage
Free radicals
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Male
Neurochemistry
Neurodegeneration
Neurology
Neuroprotection
Neuroprotective Agents - pharmacology
Neurosciences
Original Paper
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
PCB
polychlorinated biphenyls
Polychlorinated Biphenyls - toxicity
Quercetin
Quercetin - pharmacology
Rats
Rats, Wistar
Reactive oxygen species
Supplementation
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Summary:Polychlorinated biphenyls (PCBs) exposure produces neurodegeneration and induces oxidative stress. Neuroprotective role of quercetin, on PCBs induced apoptosis in hippocampus has not yet been studied. The present study is focused to see whether quercetin supplementation precludes against PCBs induced oxidative stress and hippocampal apoptosis. The results have shown that quercetin at 50 mg/kg bwt/30 days has protected oxidative stress in hippocampus of adult male rats. Quercetin, a free radical scavenger decreased the levels of oxidative stress markers in the hippocampus of simultaneous PCB+quercetin treated rats. The pro-apoptotic and anti-apoptotic molecules such as Bad, Bid, Bax and Bcl2 were altered in the hippocampus of experimental animals. PCBs increased the DNA damage and induced neurodegeneration were assessed by histological studies. PCB induced ROS may be linked to increased hippocampal neuronal apoptosis. Quercetin supplementation decreased the neuronal damage and scavenged the free radicals induced by PCBs and protects PCBs induced apoptosis and oxidative stress.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-011-0661-5