Meeting the USP and Guidelines with ICP-OES

With the implementation of USP and for the determination of metals in pharmaceutical products, the need has arisen for analysis of a wide variety of sample types, ranging from raw materials to final medications. Depending on how the medication is administered (oral, inhalation, or parenteral) and it...

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Bibliographic Details
Published in:Spectroscopy (Springfield, Or.) Or.), 2018-09, Vol.33 (s9), p.8-15
Main Authors: Hineman, Aaron, Neubauer, Ken
Format: Magazinearticle
Language:English
Subjects:
Accuracy
Analytical methods
Cost analysis
Dental materials
Emission measurements
Emission spectroscopy
Inductively coupled plasma mass spectrometry
Inhalation
Mass spectrometry
Mass spectroscopy
Materials selection
Metals
Optical emission spectroscopy
Raw materials
Respiration
Sample preparation
Scientific imaging
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Summary:With the implementation of USP and for the determination of metals in pharmaceutical products, the need has arisen for analysis of a wide variety of sample types, ranging from raw materials to final medications. Depending on how the medication is administered (oral, inhalation, or parenteral) and its daily dose, the maximum permissible exposure of the various elements changes. Although inductively coupled plasma-mass spectrometry (ICP-MS) is generally thought of as the preferred analytical method because of its ability to measure extremely low levels, ICP-optical emission spectroscopy (OES) can easily meet the requirements for many medications with low daily doses. With its advantages (compared to ICP-MS) in matrix tolerance, robustness, simplicity, and cost, ICP-OES is the technique of choice for the analysis of medications with low daily doses. This article will focus on sample preparation considerations and the analysis of a variety of medications with ICP-OES to meet the USP criteria.
ISSN:0887-6703
1939-1900