THIRTEEN-WEEK INTRAVENOUS REPEATED DOSE TOXICITY STUDY OF T-3762, A NOVEL PARENTERAL QUINOLONE ANTIMICROBIAL AGENT, AND FOUR-WEEK RECOVERY TEST IN CYNOMOLGUS MONKEYS

A thirteen-week intravenous repeated dose toxicity study of T-3762, parenteral quinolone antimicrobial agent, and four-week recovery test was carried out in male and female cynomolgus monkeys at dosages of 26, 52 and 104 mg/kg. The following results were obtained. 1) There was no death of animals du...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of antibiotics 1998/11/25, Vol.51(11), pp.625-681
Main Authors: NAGAI, AKIO, KAWAMURA, YASUHITO, KODAMA, TAKUYA, ONIMARU, TOSHIO
Format: Article
Language:Japanese
Subjects:
Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - toxicity
Body Weight - drug effects
Eating - drug effects
Female
Fluoroquinolones
Injections, Intravenous
Macaca fascicularis
Male
No-Observed-Adverse-Effect Level
Organ Size - drug effects
Time Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A thirteen-week intravenous repeated dose toxicity study of T-3762, parenteral quinolone antimicrobial agent, and four-week recovery test was carried out in male and female cynomolgus monkeys at dosages of 26, 52 and 104 mg/kg. The following results were obtained. 1) There was no death of animals during administration period at any dose levels. In general signs, there was no abnormality at any dose levels. 2) In appetite, body weights and ophthalmological examination, there was no abnormality attributable to the treatment. 3) In urinalysis, hematological examination and biochemical examination, there was no abnormality attributable to the treatment. 4) In organ weights, macroscopic findings and histopathological findings, there was no abnormality attributable to the treatment. 5) From these results in this study, no-toxic dose level of T-3762 for cynomolgus monkeys is considered over 104 mg/kg.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.51.625