Low-Density Lipoprotein Subclass Distribution Pattern and Adiposity-Associated Dyslipidemia in Postmenopausal Women

Objective: A predominance of small, dense low-density lipoprotein (LDL) particles (subclass pattern B) is associated with increased risk for coronary heart disease and is characterized by elevated triglycerides and depressed high-density lipoprotein (HDL) cholesterol concentrations. The present anal...

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Bibliographic Details
Published in:Journal of the American College of Nutrition 2000-02, Vol.19 (1), p.23-30
Main Authors: Maki, Kevin C., Davidson, Michael H., Cyrowski, Mary Sue, Maki, Ann C., Marx, Phyllis
Format: Article
Language:English
Subjects:
Adipose Tissue
Aged
Biological and medical sciences
BMI=body mass index
Body Composition
Body Constitution
body fat distribution
Cholesterol, HDL - blood
Coronary Disease - blood
Disorders of blood lipids. Hyperlipoproteinemia
EPAT=Eating Pattern Assessment Tool
Female
HDL=high-density lipoprotein
Humans
hyperlipidemia
Hyperlipidemias - blood
LDL=low-density lipoprotein
lipoproteins
Lipoproteins, LDL - blood
Lipoproteins, LDL - classification
Log
Medical sciences
MET=metabolic equivalents
Metabolic diseases
Middle Aged
natural logarithm
Obesity
Particle Size
Postmenopause
Regression Analysis
Risk Factors
Triglycerides - blood
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Summary:Objective: A predominance of small, dense low-density lipoprotein (LDL) particles (subclass pattern B) is associated with increased risk for coronary heart disease and is characterized by elevated triglycerides and depressed high-density lipoprotein (HDL) cholesterol concentrations. The present analysis was undertaken to assess the impact of LDL subclass distribution pattern and adiposity on serum lipids in postmenopausal women. Methods: Anthropometric measurements and fasting lipid data were obtained from 254 postmenopausal women 70 years of age or younger, not receiving sex hormone replacement, who were participating in a clinical trial designed to assess the influence of hormone replacement regimens on coronary heart disease risk markers. Results: The prevalence of LDL subclass pattern B was 32%. Triglyceride levels were higher and HDL cholesterol lower (both p
ISSN:0731-5724
1541-1087
DOI:10.1080/07315724.2000.10718910