Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum

  1 Department of Neuroscience and   2 Department of Psychology, University of Pittsburgh and Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania 15260;   3 Department of Psychology, Princeton University, Princeton, New Jersey 08540; and   4 Department of Biomedical Engineering, Unive...

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Published in:Journal of neurophysiology 2000-12, Vol.84 (6), p.3072-3077
Main Authors: Delgado, M. R, Nystrom, L. E, Fissell, C, Noll, D. C, Fiez, J. A
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Brain Mapping - methods
Caudate Nucleus - anatomy & histology
Caudate Nucleus - blood supply
Caudate Nucleus - physiology
Corpus Striatum - anatomy & histology
Corpus Striatum - blood supply
Corpus Striatum - physiology
Female
Gambling
Hemodynamics - physiology
Humans
Magnetic Resonance Imaging
Male
Punishment
Reward
Temporal Lobe - anatomy & histology
Temporal Lobe - blood supply
Temporal Lobe - physiology
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Summary:  1 Department of Neuroscience and   2 Department of Psychology, University of Pittsburgh and Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania 15260;   3 Department of Psychology, Princeton University, Princeton, New Jersey 08540; and   4 Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 Delgado, M. R., L. E. Nystrom, C. Fissell, D. C. Noll, and J. A. Fiez. Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum. J. Neurophysiol. 84: 3072-3077, 2000. Research suggests that the basal ganglia complex is a major component of the neural circuitry that mediates reward-related processing. However, human studies have not yet characterized the response of the basal ganglia to an isolated reward, as has been done in animals. We developed an event-related functional magnetic resonance imaging paradigm to identify brain areas that are activated after presentation of a reward. Subjects guessed whether the value of a card was higher or lower than the number 5, with monetary rewards as an incentive for correct guesses. They received reward, punishment, or neutral feedback on different trials. Regions in the dorsal and ventral striatum were activated by the paradigm, showing differential responses to reward and punishment. Activation was sustained following a reward feedback, but decreased below baseline following a punishment feedback.
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.2000.84.6.3072