Comparison of I-125 sources used for permanent interstitial implants

The increase in the number of manufacturers of 125 I sources used in prostate brachytherapy has generated many questions in the radiation oncology community. In this investigation, the physical and dosimetric characteristics were evaluated for the following sources listed by marketing company and so...

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Bibliographic Details
Published in:Medical physics (Lancaster) 2001-04, Vol.28 (4), p.671-682
Main Authors: Heintz, Bret H., Wallace, Robert E., Hevezi, James M.
Format: Article
Language:English
Subjects:
125I
Absorption
Adsorption
Anisotropy
biological organs
Biomedical modeling
brachytherapy
Brachytherapy - instrumentation
Brachytherapy - methods
Cancer
Ceramics
dosimetry
Glass
iodine
Iodine Radioisotopes
I‐125
Medical imaging
Monte Carlo Method
Physicists
radiation therapy
radioactive sources
radioisotopes
Radiometry
Resins, Plant
source
Sources of radioactive nuclei
Therapeutic applications, including brachytherapy
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Summary:The increase in the number of manufacturers of 125 I sources used in prostate brachytherapy has generated many questions in the radiation oncology community. In this investigation, the physical and dosimetric characteristics were evaluated for the following sources listed by marketing company and source model: Nycomed-Amersham 6711 (OncoSeed), Nycomed-Amersham 6702, Mentor IoGold, UroMed Symmetra, Imagyn IsoSTAR, UroCor, (PSA, Mallincrkrodt) ProstaSeed, Syncor PharmaSeed, SourceTech Medical, (BARD) 125 Implant (BrachySource), Med-Tec I-Plant, Best Medical Model 2301, DraxImage BrachySeed, and International Brachytherapy, Inc. (IBT) InterSource 125 . The investigation examined the differences in design, construction, and the dosimetric characteristics created from each source. The dosimetric characteristics of the new sources were compared to that of the Amersham 6711 source. Parameter studies have led to the development of a simple equation that can be used to clinically convert the standard 6711 source strength to an equivalent strength of a new source.
ISSN:0094-2405
2473-4209
DOI:10.1118/1.1359246