Vascular adaptation to microgravity: what have we learned?

Department of Aerospace Physiology, The Fourth Military Medical University, Xi'an 710032, China Findings from recent bed rest and spaceflight human studies have indicated that the inability to adequately elevate the peripheral resistance and the altered autoregulation of cerebral vasculature ar...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2001-12, Vol.91 (6), p.2415-2430
Main Author: Zhang, Li-Fan
Format: Article
Language:English
Subjects:
Animals
Applied physiology
Biological and medical sciences
Blood Vessels - physiology
Coronary vessels
Heart
Human physiology applied to population studies and life conditions. Human ecophysiology
Humans
Hydrostatic Pressure
Medical sciences
Models, Biological
Space Flight
Space life sciences
Stress, Physiological - etiology
Stress, Physiological - physiopathology
Transports. Aerospace. Diving. Altitude
Weightlessness
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Summary:Department of Aerospace Physiology, The Fourth Military Medical University, Xi'an 710032, China Findings from recent bed rest and spaceflight human studies have indicated that the inability to adequately elevate the peripheral resistance and the altered autoregulation of cerebral vasculature are important factors in postflight orthostatic intolerance. Animal studies with rat model have revealed that simulated microgravity may induce upward and downward regulations in the structure, function, and innervation of the cerebral and hindquarter vessels. These findings substantiate in general the hypothesis that microgravity-induced redistribution of transmural pressures and flows across and within the arterial vasculature may well initiate differential adaptations of vessels in different anatomic regions. Understanding of the mechanisms involved in vascular adaptation to microgravity is also important for the development of multisystem countermeasures. However, future studies will be required to further ascertain the peripheral effector mechanism of postflight cardiovascular dysfunction. cardiovascular deconditioning; postflight orthostatic intolerance; arteries; arterioles; remodeling; vasoreactivity; perivascular nerves; countermeasures
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.2001.91.6.2415