No evidence for HPA reset in adult sheep with high blood pressure due to short prenatal exposure to dexamethasone

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville 3052, Victoria, Australia Exposure of pregnant ewes to dexamethasone, for only 2 days (term ~150 days) at 27 days of gestation ( group D ), results in adult offspring with high blood pressure. In this...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2002-02, Vol.282 (2), p.343-R350
Main Authors: Dodic, Miodrag, Peers, Arianne, Moritz, Karen, Hantzis, Vicky, Wintour, E. Marelyn
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Age Factors
Animals
Arginine Vasopressin - blood
Blood Volume - physiology
Dexamethasone - pharmacology
Female
Gene Expression - physiology
Glucocorticoids - pharmacology
Hemorrhage - physiopathology
Hydrocortisone - blood
Hypertension - chemically induced
Hypertension - physiopathology
Hypothalamo-Hypophyseal System - physiology
Pituitary-Adrenal System - physiology
Pregnancy
Prenatal Exposure Delayed Effects
Receptors, Glucocorticoid - genetics
Receptors, Mineralocorticoid - genetics
Renin - blood
Sheep
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Summary:Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville 3052, Victoria, Australia Exposure of pregnant ewes to dexamethasone, for only 2 days (term ~150 days) at 27 days of gestation ( group D ), results in adult offspring with high blood pressure. In this study, hemorrhage stress has been used to see whether in these animals the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis is altered. In addition, we studied mineralocorticoid (MR) and glucocorticoid (GR) receptor gene expression in the hippocampus and GR gene expression in the hypothalamus using real-time PCR. Calculated areas under the adrenocorticotropin, arginine vasopressin, and cortisol plasma concentration curves in response to hemorrhage were similar between the control and group D . In addition, there was no significant difference in the expression of MR and GR in the hippocampus or GR in the hypothalamus between the control and group D . Taken together, it is unlikely that reset in the HPA axis plays a major role in this particular model of "programmed" hypertension. glucocorticoid receptor; mineralocorticoid receptor; messenger ribonucleic acid; hypothalamo-pituitary-adrenal axis
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.00222.2001