Molecular Dissection of Hippocampal Theta-Burst Pairing Potentiation

Long-term potentiation (LTP) of synaptic efficacy in the hippocampus is frequently induced by tetanic stimulation of presynaptic afferents or by pairing low frequency stimulation with postsynaptic depolarization. Adult (P42) GluR-A-/-mice largely lack these forms of LTP. LTP in wt mice can also be i...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2002-05, Vol.99 (11), p.7740-7745
Main Authors: Hoffman, D. A., Sprengel, R., Sakmann, B.
Format: Article
Language:English
Subjects:
2-Amino-5-phosphonovalerate - pharmacology
Action potentials
Action Potentials - physiology
Animals
Biological Sciences
Depolarization
Egtazic Acid - analogs & derivatives
Egtazic Acid - pharmacology
Electric potential
Hippocampus
Hippocampus - drug effects
Hippocampus - physiology
Long term potentiation
Long-Term Potentiation - drug effects
Long-Term Potentiation - physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Molecular biology
Neurons
Neuroscience
Protein Subunits
Receptors, AMPA - deficiency
Receptors, AMPA - genetics
Receptors, AMPA - physiology
Rodents
Sensors
Synapses - physiology
Tetanus
Theta Rhythm - drug effects
Working memory
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Summary:Long-term potentiation (LTP) of synaptic efficacy in the hippocampus is frequently induced by tetanic stimulation of presynaptic afferents or by pairing low frequency stimulation with postsynaptic depolarization. Adult (P42) GluR-A-/-mice largely lack these forms of LTP. LTP in wt mice can also be induced by coincident pre- and postsynaptic action potentials, where an initial rapid component is expressed but a substantial fraction of the potentiation develops with a delayed time course. We report here that this stimulation protocol, delivered at theta frequency (5 Hz), induces LTP in GluR-A-/-mice in which the initial component is substantially reduced. The remaining GluR-A independent component differs from the initial component in that its expression develops over time after induction and its induction is differentially dependent on postsynaptic intracellular Ca2+buffering. Thus, in adult mice, theta-burst pairing evokes two forms of synaptic potentiation that are induced simultaneously but whose expression levels vary inversely with time. The two components of synaptic potentiation could be relevant for different forms of information storage that are dependent on hippocampal synaptic transmission such as spatial reference and working memory.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.092157999