The DAU allele cluster of the RHD gene

Variant D occurs frequently in Africans. However, considerably less RHD alleles have been described in this population compared with Europeans. We characterized 5 new RHD alleles, dubbed DAU-0 to DAU-4, that shared a T379M substitution and occurred in a cDe haplotype. DAU-1 to DAU-4 were detected in...

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Bibliographic Details
Published in:Blood 2002-07, Vol.100 (1), p.306-311
Main Authors: WAGNER, Franz F, LADEWIG, Birgit, ANGERT, Katharina S, HEYMANN, Guido A, ETCHER, Nicole I, FLEGEL, Willy A
Format: Article
Language:English
Subjects:
Africa - epidemiology
African Continental Ancestry Group - genetics
Alleles
Amino Acid Substitution - immunology
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Epitopes - genetics
Genetic Variation - genetics
Genetic Variation - immunology
Humans
Medical sciences
Multigene Family
Phenotype
Phylogeny
Polymorphism, Single Nucleotide
Rh Isoimmunization - genetics
Rh-Hr Blood-Group System - genetics
Rh-Hr Blood-Group System - immunology
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:Variant D occurs frequently in Africans. However, considerably less RHD alleles have been described in this population compared with Europeans. We characterized 5 new RHD alleles, dubbed DAU-0 to DAU-4, that shared a T379M substitution and occurred in a cDe haplotype. DAU-1 to DAU-4 were detected in Africans with partial D phenotypes. They harbored one and 2 additional missense mutations, respectively, dispersed throughout the RhD protein. An anti-D immunization was found in DAU-3. DAU-0 carrying T379M only was detected by screening European blood donors and expressed a normal D phenotype. Within the phylogeny of the RHD alleles, DAU formed an independent allele cluster, separate from the DIVa, weak D type 4, and Eurasian D clusters. The characterization of the RH phylogeny provided a framework for future studies on RH alleles. The identification of the DAU alleles increased the number of known partial D alleles in Africans considerably. DAU alleles may be a major cause of antigen D variability and anti-D immunization in patients of African descent.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2002-01-0320