Selective REM sleep deprivation during daytime: I. Time course of interventions and recovery sleep

Institute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland Although repeated selective rapid eye movement (REM) sleep deprivation by awakenings during nighttime has shown that the number of sleep interruptions required to prevent REM sleep increases within and across co...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2002-08, Vol.283 (2), p.521-R526
Main Authors: Werth, Esther, Cote, Kimberly A, Gallmann, Eva, Borbely, Alexander A, Achermann, Peter
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Circadian Rhythm - physiology
Computer Simulation
Electroencephalography
Homeostasis - physiology
Humans
Light
Male
Models, Biological
Polysomnography
Reference Values
Sleep Deprivation - physiopathology
Time Factors
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Summary:Institute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland Although repeated selective rapid eye movement (REM) sleep deprivation by awakenings during nighttime has shown that the number of sleep interruptions required to prevent REM sleep increases within and across consecutive nights, the underlying regulatory processes remained unspecified. To assess the role of circadian and homeostatic factors in REM sleep regulation, REM sleep was selectively deprived in healthy young adult males during a daytime sleep episode (7-15 h) after a night without sleep. Circadian REM sleep propensity is known to be high in the early morning. The number of interventions required to prevent REM sleep increased from the first to the third 2-h interval by a factor of two and then leveled off. Only a minor REM sleep rebound (11.6%) occurred in the following undisturbed recovery night. It is concluded that the limited rise of interventions during selective daytime REM sleep deprivation may be due to the declining circadian REM sleep propensity, which may partly offset the homeostatic drive and the sleep-dependent disinhibition of REM sleep. non-rapid eye movement sleep; sleep homeostasis; sleep regulation; spectral analysis
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.00462.2001