Gonadal function in male adolescents and young males with juvenile onset systemic lupus erythematosus

OBJECTIVE: To evaluate gonadal function in male adolescents and young men with juvenile onset systemic lupus erythematosus (SLE). METHODS: Four young men with SLE underwent clinical and laboratory evaluation, testicular ultrasound, follicle stimulating hormone, luteinizing hormone, prolactin, testos...

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Bibliographic Details
Published in:Journal of rheumatology 2002-09, Vol.29 (9), p.2000-2005
Main Authors: SILVA, Clovis A. A, HALLAK, Jorge, PASQUALOTTO, Fabio F, BARBA, Mario F, SAITO, Maria I, KISS, Maria H. B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Dermatology
Follicle Stimulating Hormone - analysis
Humans
Hypogonadism - diagnosis
Hypogonadism - etiology
Infertility, Male - diagnosis
Infertility, Male - etiology
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Luteinizing Hormone - analysis
Male
Medical sciences
Oligospermia - diagnosis
Oligospermia - etiology
Prognosis
Risk Assessment
Sampling Studies
Semen - cytology
Skin involvement in other diseases. Miscellaneous. General aspects
Sperm Count
Sperm Motility
Testosterone - analysis
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Summary:OBJECTIVE: To evaluate gonadal function in male adolescents and young men with juvenile onset systemic lupus erythematosus (SLE). METHODS: Four young men with SLE underwent clinical and laboratory evaluation, testicular ultrasound, follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, and anti-sperm antibody determination. The semen analyses were performed according to the WHO guidelines and Kruger strict criteria. All patients were asked to provide 3 semen samples over a period of 2 months. A new sample was collected 6 months later. RESULTS: The median disease duration was 6.6 years. The median age at initial ejaculation was 13.5 years. All 4 patients had severe disease with renal involvement (WHO class IV or V). The SLICC/ACR damage index at the time of study entry ranged between 0 and 3. The patients' Tanner stage was P5G5; all reported normal erection and libido. Gonadal evaluation by thorough examination of the genitalia and ultrasound was normal. Anti-sperm antibodies were negative in all patients. Only one patient showed high FSH and LH levels. The initial and final semen evaluations of the 4 patients were abnormal (azoospermia, oligoastenoteratospermia, or teratospermia). One patient was receiving azathioprine and 2 were receiving cyclophosphamide at the time of study entry. CONCLUSION: Although these patients had normal sexual activity and normal external genitalia, their fertility was decreased based on the sperm abnormalities. Serial semen analyses in larger study populations will be necessary to clarify the degree and duration of sperm abnormalities in male patients with SLE in general.
ISSN:0315-162X
1499-2752