Granzymes are essential for natural killer cell‐mediated and perf‐facilitated tumor control

Studies with perforin‐deficient mice firmly established perforin as a key element in cytotoxic T cell (CTL) / natural killer (NK) cell‐mediated tumor control but did not reveal the role of granzyme (gzm) A and B. A contribution of gzm in these processes was indicated by earlier in vitro experiments...

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Bibliographic Details
Published in:European journal of immunology 2002-10, Vol.32 (10), p.2881-2886
Main Authors: Pardo, Julián, Balkow, Sandra, Anel, Alberto, Simon, Markus M.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cytotoxicity, Immunologic
Granzyme
Granzymes
Killer Cells, Natural - immunology
Membrane Glycoproteins - physiology
Mice
Mice, Inbred C57BL
Natural killer cell
Neoplasms, Experimental - immunology
Perforin
Pore Forming Cytotoxic Proteins
Serine Endopeptidases - physiology
Tumor Cells, Cultured
Tumor growth
Online Access:Get full text
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