Cisplatin–etoposide alternating with topotecan in patients with extensive stage small cell lung cancer (SCLC): A multicenter phase II study

• Published in: Lung cancer (Amsterdam, Netherlands) Netherlands), 2002-10, Vol.38 (1), p.59-63
• Main Authors: Mavroudis, D, Veslemes, M, Kouroussis, Ch, Tzanakis, N, Ferdoutsis, E, Toumbis, M, Ziotopoulos, P, Agelidou, M, Tselepatiotis, E, Kalbakis, K, Souglakos, J, Magkanas, E, Samonis, G, Georgoulias, V, Group, for the Hellenic Oncology Research
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alternating; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Carcinoma, Small Cell - drug therapy; Carcinoma, Small Cell - pathology; Chemotherapy; Cisplatin; Cisplatin - administration & dosage; Disease Progression; Drug Administration Schedule; Etoposide; Etoposide - administration & dosage; Female; Humans; Infusions, Intravenous; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Male; Medical sciences; Middle Aged; Neoplasm Staging; Neutropenia - chemically induced; Pharmacology. Drug treatments; Small cell lung cancer; Survival; Thrombocytopenia - chemically induced; Topotecan; Topotecan - administration & dosage; Treatment Outcome
• ISSN: 0169-5002; 1872-8332
• DOI: 10.1016/S0169-5002(02)00149-6

Purpose: In order to investigate the feasibility of a potentially non-cross resistant drug regimen, we alternated cycles of cisplatin–etoposide with topotecan as front-line treatment in patients with extensive stage small cell lung cancer (SCLC). Patients and Methods: Thirty-six previously untreated patients with extensive stage SCLC received cisplatin 75 mg/m 2 IV on day 1 and etoposide 100 mg/m 2 IV on days 1–3 on cycles one, three, five and seven and topotecan 1.5 mg/m 2 IV on days 1–5 on cycles two, four, six and eight. Cycles were repeated every 21 days. Patients' median age was 60 years and performance status (WHO) was 0 for 13, 1 for 20 and 2 for three patients. All patients were evaluable for response and toxicity. Results: Five (14%) patients achieved a complete response and 18 (50%) a partial response for an overall response rate of 64% (95% confidence interval: 48.2–79.6%). After a median follow up of 10 months, the median duration of response was 5.5 months, the time to tumor progression 8 months and the probability of 1-year survival 48.9%. A total of 126 cycles of cisplatin–etoposide and 117 cycles of topotecan were administered with a median number of 4 cycles/patient for each regimen. There were no toxic deaths. Treatment delays due to toxicity occurred in 13 (10%) cycles after cisplatin–etoposide and 16 (14%) cycles after topotecan while doses were reduced in seven (6%) and five (4%) cycles, respectively. Grade 3–4 neutropenia, thrombocytopenia and febrile neutropenia complicated 13, 1 and 3% of cisplatin–etoposide cycles and 28, 6 and 1% of topotecan, respectively. Non-hematologic toxicity was mild. The delivered dose intensity was 96% for cisplatin and etoposide and 98% for topotecan. Conclusions: The alternating administration of cisplatin–etoposide and topotecan is a feasible, active and well-tolerated regimen in patients with extensive stage SCLC.