Antioxidants attenuate the plasma cytokine response to exercise in humans

Department of Critical Care and Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, GR-10675 Athens, Greece Exercise increases plasma TNF- , IL-1 , and IL-6, yet the stimuli and sources of TNF- and IL-1 remain largely unknown. We tested the role of oxidative stress and th...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2003-03, Vol.94 (3), p.1025-1032
Main Authors: Vassilakopoulos, Theodoros, Karatza, Maria-Helena, Katsaounou, Paraskevi, Kollintza, Androniki, Zakynthinos, Spyros, Roussos, Charis
Format: Article
Language:English
Subjects:
Acetylcysteine - pharmacology
Adult
Allopurinol - pharmacology
Antimetabolites - pharmacology
Antioxidants
Antioxidants - pharmacology
Ascorbic Acid - pharmacology
Biological and medical sciences
Creatine Kinase - blood
Cytokines - blood
Exercise
Exercise - physiology
Flow Cytometry
Free Radical Scavengers - pharmacology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Interleukin-1 - biosynthesis
Male
Modulation of the immune response (stimulation, suppression)
Monocytes - metabolism
Plasma
Reactive Oxygen Species - blood
Vitamin A - pharmacology
Vitamin E - pharmacology
Vitamins
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Summary:Department of Critical Care and Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, GR-10675 Athens, Greece Exercise increases plasma TNF- , IL-1 , and IL-6, yet the stimuli and sources of TNF- and IL-1 remain largely unknown. We tested the role of oxidative stress and the potential contribution of monocytes in this cytokine (especially IL-1 ) response in previously untrained individuals. Six healthy nonathletes performed two 45-min bicycle exercise sessions at 70% of O 2 max before and after a combination of antioxidants (vitamins E, A, and C for 60 days; allopurinol for 15 days; and N -acetylcysteine for 3 days). Blood was drawn at baseline, end-exercise, and 30 and 120 min postexercise. Plasma cytokines were determined by ELISA and monocyte intracellular cytokine level by flow cytometry. Before antioxidants, TNF- increased by 60%, IL-1 by threefold, and IL-6 by sixfold secondary to exercise ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00735.2002