Reduced exercise arteriovenous O2 difference in Type 2 diabetes

Departments of 1  Sport and Exercise Science and 2  Cardiovascular Research, School of Medicine, University of Auckland, Auckland, New Zealand Maximal O 2 consumption ( O 2 max ) is lower in individuals with Type 2 diabetes than in sedentary nondiabetic individuals. This study aimed to determine whe...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2003-03, Vol.94 (3), p.1033-1038
Main Authors: Baldi, James C, Aoina, James L, Oxenham, Helen C, Bagg, Warwick, Doughty, Robert N
Format: Article
Language:English
Subjects:
Adult
Anaerobic Threshold - physiology
Biological and medical sciences
Blood vessels
Carbon Dioxide
Cardiac Output - physiology
Circulatory system
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Exercise
Exercise - physiology
Female
Hemodynamics - physiology
Humans
Male
Management. Various non-drug treatments. Langerhans islet grafts
Medical sciences
Middle Aged
Oxygen
Oxygen - blood
Oxygen Consumption - physiology
Pulmonary Gas Exchange - physiology
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Summary:Departments of 1  Sport and Exercise Science and 2  Cardiovascular Research, School of Medicine, University of Auckland, Auckland, New Zealand Maximal O 2 consumption ( O 2 max ) is lower in individuals with Type 2 diabetes than in sedentary nondiabetic individuals. This study aimed to determine whether the lower O 2 max in diabetic patients was due to a reduction in maximal cardiac output ( max ) and/or peripheral O 2 extraction. After 11 Type 2 diabetic patients and 12 nondiabetic subjects, matched for age and body composition, who had not exercised for 2 yr, performed a bicycle ergometer exercise test to determine O 2 max , submaximal cardiac output, max , and arterial-mixed venous O 2 (a- O 2 ) difference were assessed. Maximal workload, O 2 max , and maximal a- O 2 difference were lower in Type 2 diabetic patients ( P   0.05). Submaximal O 2 uptake and heart rate were lower at several workloads in diabetic patients; respiratory exchange ratio was similar between groups at all workloads. O 2 max was linearly correlated with a- O 2 difference, but not max in diabetic patients. These data suggest that a reduction in maximal a- O 2 difference contributes to a decreased O 2 max in Type 2 diabetic patients. maximal aerobic capacity; cardiac output
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00879.2002