Closed-loop glucose control in critically ill patients using continuous glucose monitoring system (CGMS) in real time

A study was conducted to determine if continuous subcutaneous glucose monitoring (from MiniMed CGMS) could be used in real-time to control blood sugar level (BSL) in patients with critical illness. A closed-loop control system was constructed to use CGMS in a real-time manner, coupled with a proport...

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Bibliographic Details
Published in:IEEE journal of biomedical and health informatics 2003-03, Vol.7 (1), p.43-53
Main Authors: Chee, F., Fernando, T., van Heerden, P.V.
Format: Article
Language:English
Subjects:
Algorithms
Automatic control
Biomedical monitoring
Biosensors
Blood
Clinical Trials as Topic
Control algorithms
Control systems
Critical Illness
Glucose
Glucose - analysis
Humans
Monitoring
Monitoring systems
Monitoring, Physiologic - instrumentation
Monitoring, Physiologic - methods
Patient monitoring
Patients
Pi control
Proportional control
Real time
Real time systems
Sensors
Sliding
Sugar
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Summary:A study was conducted to determine if continuous subcutaneous glucose monitoring (from MiniMed CGMS) could be used in real-time to control blood sugar level (BSL) in patients with critical illness. A closed-loop control system was constructed to use CGMS in a real-time manner, coupled with a proportional integral (PI) control algorithm based on a sliding scale approach, for automatic intravenous infusion of insulin to patients. A total of five subjects with high BSL (>10 mmol/L) participated in formal studies of the closed-loop control system. Subjects were recruited from critically ill patients in the intensive care unit (ICU) after informed consent was obtained. Error grid analysis showed that 64.6% of the BSL readings as determined in real time using CGMS sensor, when compared to conventional BSL measurements on blood drawn from an arterial line, was clinically accurate (i.e.,
ISSN:1089-7771
2168-2194
1558-0032
2168-2208
DOI:10.1109/TITB.2003.808509