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A 39-kDa Protein on Activated Helper T Cells Binds CD40 and Transduces the Signal for Cognate Activation of B Cells

CD40 is a B-cell surface molecule that has been shown to induce B-cell growth upon ligation with monoclonal antibodies. This report shows that triggering via CD40 is essential for the activation of resting B cells by helper T cells (Th). A soluble fusion protein of CD40 and human immunoglobulin, CD4...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1992-07, Vol.89 (14), p.6550-6554
Main Authors: Noelle, Randolph J., Roy, Meenakshi, Shepherd, David M., Stamenkovic, Ivan, Ledbetter, Jeffrey A., Aruffo, Alejandro
Format: Article
Language:English
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Summary:CD40 is a B-cell surface molecule that has been shown to induce B-cell growth upon ligation with monoclonal antibodies. This report shows that triggering via CD40 is essential for the activation of resting B cells by helper T cells (Th). A soluble fusion protein of CD40 and human immunoglobulin, CD40-Ig, inhibited the induction of B-cell cycle entry, proliferation, and differentiation by activated Th1 and Th2. The ligand for CD40 was identified as a 39-kDa membrane protein that was selectively expressed on activated Th. A monoclonal antibody specific for the 39-kDa protein inhibited CD40-Ig binding and also inhibited the activation of B cells by Th. These data indicate that the 39-kDa membrane protein expressed on activated This a binding protein for CD40 and functions to transduce the signal for Th-dependent B-cell activation.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.89.14.6550