The Role of MAP Kinases in Trauma and Ischemia-Reperfusion

Mitogen-activated protein kinases (MAPKs) have been the focus of a number of studies, as these compounds are involved in a number of important inflammatory cell signaling mechanisms. Recent studies have further elucidated the role of MAPKs in the inflammatory response, as a result of trauma and/or i...

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Bibliographic Details
Published in:Journal of investigative surgery 2004, Vol.17 (1), p.45-53
Main Authors: Lai, Edwin W., Toledo-Pereyra, Luis H., Walsh, Jon, Lopez-Neblina, F., Anaya-Prado, R.
Format: Article
Language:English
Subjects:
Animals
ERK
Humans
ischemia-reperfusion
MAPKs
Mitogen-Activated Protein Kinases - metabolism
Reperfusion Injury - metabolism
SAP/JNK
trauma
Wounds and Injuries - metabolism
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Summary:Mitogen-activated protein kinases (MAPKs) have been the focus of a number of studies, as these compounds are involved in a number of important inflammatory cell signaling mechanisms. Recent studies have further elucidated the role of MAPKs in the inflammatory response, as a result of trauma and/or ischemia-reperfusion (I/R) injury. There are three major classes of MAPKs that may be involved in the inflammatory response: extracellular signal-regulated kinases (ERKs), stress-activated protein kinases (SAPKs)/c-Jun NH2-terminal kinases (JNKs), and p38 MAPKs (p38). This is clinically relevant, because these pathways may be a possible target for anti-inflammatory drug intervention. This review studies the role of MAPKs in trauma and/or I/R.
ISSN:0894-1939
1521-0553
DOI:10.1080/08941930490269646