Synthesis of 2′-Substituted MMI Linked Nucleosidic Dimers: An Optimization Study in Search of High Affinity Oligonucleotides for Use in Antisense Constructs

The synthesis of a series of methylene(methylimino) (MMI) linked oligodeoxyribonucleotide dimers modified at the 2′-position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, bis 2′-OMe MMI dimer was selected for further stud...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2004-01, Vol.23 (1-2), p.411-438
Main Authors: Peoc'h, Didier, Swayze, Eric E., Bhat, Balkrishen, Sanghvi, Yogesh S.
Format: Article
Language:English
Subjects:
Antisense
Dimerization
DNA, Antisense - chemistry
MMI dimer
Nucleosides - chemical synthesis
Nucleosides - chemistry
Oligonucleotide
RNA, Antisense - chemistry
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Summary:The synthesis of a series of methylene(methylimino) (MMI) linked oligodeoxyribonucleotide dimers modified at the 2′-position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, bis 2′-OMe MMI dimer was selected for further studies based on its synthetic accessibility and the increased thermodynamic stability conferred upon oligonucleotides incorporating this modification. † In honor and celebration of the 70th birthday of Professor Leroy B. Townsend.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-120028337