Cyclooxygenase-2 Expression in Human Gastric Tubular Adenomas and Carcinomas; Correlation with Intratumoral Microvessel Density and Apoptotic Index

Background: Cyclooxygenase (COX)-2 plays an important role in carcinogenesis in various human malignancies. This study examined the relationship among COX-2 expression, angiogenesis and apoptosis in human gastric adenoma and carcinoma. Materials and Methods: We examined the expression of COX-2 in 30...

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Bibliographic Details
Published in:Anticancer research 2004-05, Vol.24 (3A), p.1439-1444
Main Authors: HONJO, Soicfiiro, KASE, Satoru, OSAKI, Mitsuhiko, ARDYANTO, Tonang Dwi, KAIBARA, Nobuaki, ITO, Hisao
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood supply
Adenocarcinoma - enzymology
Adenocarcinoma - pathology
Adenoma - blood supply
Adenoma - enzymology
Adenoma - pathology
Apoptosis - physiology
Biological and medical sciences
Cell Division - physiology
Cyclooxygenase 2
Humans
Immunohistochemistry
Isoenzymes - biosynthesis
Medical sciences
Membrane Proteins
Neovascularization, Pathologic - enzymology
Neovascularization, Pathologic - pathology
Prostaglandin-Endoperoxide Synthases - biosynthesis
Stomach Neoplasms - blood supply
Stomach Neoplasms - enzymology
Stomach Neoplasms - pathology
Tumors
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Summary:Background: Cyclooxygenase (COX)-2 plays an important role in carcinogenesis in various human malignancies. This study examined the relationship among COX-2 expression, angiogenesis and apoptosis in human gastric adenoma and carcinoma. Materials and Methods: We examined the expression of COX-2 in 30 tubular adenomas and 111 carcinomas, comparing it with intratumoral microvessel density (IMVD) and apoptotic index (AI) by immunohistochemistry and the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-digoxygenin nick-end labeling (TUNEL) procedure. Results: Immunohistochemistry demonstrated positive expression of COX-2 in 15 (50.0%) adenomas and in 50 (53.1%) carcinomas, respectively. The frequency of COX-2 expression was signficantly higher in intestinal-type carcinomas than in diffuse-type, regardless of the tumor stage. The IMVD was significantly higher in the early and advanced carcinomas than in the adenomas and also higher in the COX-2-positive adenomas and carcinomas than in the negative ones. The AI was significantly higher in the adenomas than in the carcinomas and also in the COX-2-negative adenomas and intestinal-type early carcinomas than in their positive counterparts, respectively (p
ISSN:0250-7005
1791-7530