Second trimester maternal serum biochemical screening for Down's syndrome: experience of a single obstetric unit

The objective of this study was to assess the effects of mid-trimester biochemical screening on the prenatal diagnosis of Down's syndrome. All patients booked for antenatal care at the Royal Free Hospital are offered a double marker biochemical screening test (alpha-fetoprotein and free beta hu...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 1999, Vol.19 (4), p.373-376
Main Authors: Kadir, R A, Pepera, T, Economides, D L
Format: Article
Language:English
Subjects:
Downs syndrome
Medical screening
Obstetrics
Pregnancy
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Summary:The objective of this study was to assess the effects of mid-trimester biochemical screening on the prenatal diagnosis of Down's syndrome. All patients booked for antenatal care at the Royal Free Hospital are offered a double marker biochemical screening test (alpha-fetoprotein and free beta human chorionic gonadotrophin). The results of double marker screening tests and the notes of all cases of trisomy 21 from 1 April 1993 to 31 March 1995 were reviewed. Of the 6170 women booked in the antenatal clinic during this 2-year period 4427 (71.8%) took up the offer of biochemical screening. Four hundred and twenty-nine (9.7% of those screened) were reported positive and 293 karyotypes were performed in this group (68.3% uptake) and 253 karyotypes were also performed for other indications. Thirteen of 21 affected pregnancies had biochemical screening. The detection rate of biochemical screening in women aged
ISSN:0144-3615
1364-6893
DOI:10.1080/01443619964670