Error-prone DNA repair and translesion dna synthesis II : The inducible SOS hypothesis

Evelyn Witkin hypothesized in 1967 that bacterial cell division is controlled by a repressor which, like the lambda repressor, is inactivated by a complex process that starts with the presence of replication-blocking lesions in the DNA. She further suggested that this might not be the only cellular...

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Bibliographic Details
Published in:DNA repair 2005-06, Vol.4 (6), p.725-739
Main Author: BRIDGES, Bryn A
Format: Article
Language:English
Subjects:
Bacteriology
Biological and medical sciences
DNA Repair
DNA Replication
DNA, Bacterial
Dose-Response Relationship, Radiation
Escherichia coli - genetics
Escherichia coli - radiation effects
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Bacterial
Genes, Bacterial
Growth, nutrition, cell differenciation
Microbiology
Molecular and cellular biology
Molecular genetics
Mutagenesis. Repair
Mutation
SOS Response (Genetics)
Ultraviolet Rays
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Summary:Evelyn Witkin hypothesized in 1967 that bacterial cell division is controlled by a repressor which, like the lambda repressor, is inactivated by a complex process that starts with the presence of replication-blocking lesions in the DNA. She further suggested that this might not be the only cellular function to show induction by DNA damage. Three years later, Miroslav Radman, in a privately circulated note, proposed that one such function might be an inaccurate (mutation-prone) DNA polymerase under the control of the recA and lexA genes. Thus was born the SOS hypothesis.
ISSN:1568-7864
1568-7856
DOI:10.1016/j.dnarep.2004.12.009