Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock

A considerable amount of research has focused on elucidating the mechanisms by which cytokines synthesized by cells of the innate immune system participate in the life-threatening multiple-organ failure of endotoxic shock. We show here that alphabeta T cells, which are archetypes of the adaptive cel...

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Bibliographic Details
Published in:The Journal of infectious diseases 2005-09, Vol.192 (6), p.1039
Main Authors: Jones-Carson, Jessica, Fantuzzi, Giamila, Siegmund, Britta, Dinarello, Charles, Tracey, Kevin J, Wang, Haichao, Fang, Ferric C, Vazquez-Torres, Andres
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Endotoxemia - immunology
Immunity, Innate
Lipopolysaccharides - toxicity
Mice
Mice, Inbred C57BL
Receptors, Antigen, T-Cell, alpha-beta - immunology
Shock, Septic - immunology
Survival Analysis
T-Lymphocytes, Regulatory - immunology
Transforming Growth Factor beta - analysis
Transforming Growth Factor beta - blood
Tumor Necrosis Factor-alpha - analysis
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Summary:A considerable amount of research has focused on elucidating the mechanisms by which cytokines synthesized by cells of the innate immune system participate in the life-threatening multiple-organ failure of endotoxic shock. We show here that alphabeta T cells, which are archetypes of the adaptive cellular immune response, suppress the proinflammatory cascade triggered during the early stages of lipopolysaccharide (LPS)-induced endotoxemia. The absence of alphabeta T cells led to the fulminant death of LPS-challenged mice, coinciding with a massive release of the proinflammatory cytokines tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma and a marked reduction in the synthesis of the immunosuppressive cytokine transforming growth factor (TGF)-beta. Cytotoxic T lymphocyte antigen (CTLA)-positive alphabeta T cells emerging shortly after LPS challenge appear to control TGF-beta synthesis. The neutralization of either TGF-beta or CTLA4 resulted in similar increases in IFN-gamma and TNF-alpha serum concentrations in LPS-challenged mice. These observations suggest that suppressor alphabeta T lymphocytes protect against the proinflammatory cascade unleashed during the innate stages of endotoxemia.
ISSN:0022-1899