Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland

In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity. There is a high selectivity in the transport of immunoglobulins from the maternal plasma across the mammary barrier into the colostrum, and only IgG1 is transferred in large amounts. W...

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Bibliographic Details
Published in:Journal of dairy research 2005, Vol.72 Spec No, p.107
Main Authors: Mayer, Balázs, Doleschall, Márton, Bender, Balázs, Bartyik, János, Bosze, Zsuzsanna, Frenyó, László V, Kacskovics, Imre
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological Transport
Cattle
Colostrum - immunology
Epithelial Cells - chemistry
Female
Gene Expression
Immunoglobulin G - metabolism
Immunohistochemistry
In Situ Hybridization
Mammary Glands, Animal - chemistry
Mammary Glands, Animal - growth & development
Parturition
Pregnancy
Receptors, Fc - analysis
Receptors, Fc - genetics
Receptors, Fc - physiology
Reverse Transcriptase Polymerase Chain Reaction
Tissue Distribution
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Summary:In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity. There is a high selectivity in the transport of immunoglobulins from the maternal plasma across the mammary barrier into the colostrum, and only IgG1 is transferred in large amounts. We have recently analysed the expression of the neonatal Fc receptor (FcRn) in sheep mammary gland around parturition. Re-analysing this issue in bovine confirmed our previous data indicating that FcRn is homogeneously localized in the mammary gland acinar cells before parturition, however a remarkable difference was observed in the pattern after calving, where only the apical side of the cells was strongly stained. The presence of the FcRn in the acinar epithelial cells of the mammary gland and the obvious change in distribution before and after parturition indicate that FcRn plays an important role in the IgG transport during colostrum formation in ruminants.
ISSN:0022-0299
DOI:10.1017/S0022029905001135