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Neuroprotective 2-(2-Phenylethyl)chromones of Imperata cylindrica
Bioactivity-guided fractionation of the methanolic extract of the rhizomes of Imperata cylindrica afforded a new compound, 5-hydroxy-2-(2-phenylethyl)chromone (1), together with three known compounds, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (2), flidersiachromone (3), and 5-hydroxy-2-styrylch...
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| Published in: | Journal of natural products (Washington, D.C.) D.C.), 2006-02, Vol.69 (2), p.290-291 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 291 |
| container_issue | 2 |
| container_start_page | 290 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 69 |
| creator | Yoon, J.S Lee, M.K Sung, S.H Kim, Y.C |
| description | Bioactivity-guided fractionation of the methanolic extract of the rhizomes of Imperata cylindrica afforded a new compound, 5-hydroxy-2-(2-phenylethyl)chromone (1), together with three known compounds, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (2), flidersiachromone (3), and 5-hydroxy-2-styrylchromone (4). Among these four compounds, 1 and 2 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells. |
| doi_str_mv | 10.1021/np0503808 |
| format | article |
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Among these four compounds, 1 and 2 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np0503808</identifier><identifier>PMID: 16499335</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>2-(phenylethyl)chromone ; Adrenal Cortex - cytology ; Adrenal Cortex - drug effects ; Animals ; Biological and medical sciences ; Cells, Cultured ; chemical structure ; Chromones - chemistry ; Chromones - isolation & purification ; Chromones - pharmacology ; flavonoids ; General pharmacology ; Glutamic Acid - pharmacology ; Imperata cylindrica ; Korea ; Medical sciences ; medicinal plants ; neurons ; Neuroprotective Agents - chemistry ; Neuroprotective Agents - isolation & purification ; Neuroprotective Agents - pharmacology ; neuroprotective effect ; Pharmacognosy. 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Drug treatments ; Plants, Medicinal - chemistry ; Poaceae - chemistry ; Rats ; Rhizome ; spectral analysis ; traditional medicine</subject><ispartof>Journal of natural products (Washington, D.C.), 2006-02, Vol.69 (2), p.290-291</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17581628$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16499335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, J.S</creatorcontrib><creatorcontrib>Lee, M.K</creatorcontrib><creatorcontrib>Sung, S.H</creatorcontrib><creatorcontrib>Kim, Y.C</creatorcontrib><title>Neuroprotective 2-(2-Phenylethyl)chromones of Imperata cylindrica</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Bioactivity-guided fractionation of the methanolic extract of the rhizomes of Imperata cylindrica afforded a new compound, 5-hydroxy-2-(2-phenylethyl)chromone (1), together with three known compounds, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (2), flidersiachromone (3), and 5-hydroxy-2-styrylchromone (4). Among these four compounds, 1 and 2 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.</description><subject>2-(phenylethyl)chromone</subject><subject>Adrenal Cortex - cytology</subject><subject>Adrenal Cortex - drug effects</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>chemical structure</subject><subject>Chromones - chemistry</subject><subject>Chromones - isolation & purification</subject><subject>Chromones - pharmacology</subject><subject>flavonoids</subject><subject>General pharmacology</subject><subject>Glutamic Acid - pharmacology</subject><subject>Imperata cylindrica</subject><subject>Korea</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>neurons</subject><subject>Neuroprotective Agents - chemistry</subject><subject>Neuroprotective Agents - isolation & purification</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>neuroprotective effect</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>Poaceae - chemistry</subject><subject>Rats</subject><subject>Rhizome</subject><subject>spectral analysis</subject><subject>traditional medicine</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpFzztPwzAUhmELgWgpDPwByIIEQ-DYjh1nrCoulQoUtV26RCeOTQO5yUkR-fcElct0hvPolT5CTilcU2D0pqxBAFeg9siQCga-BCb2yRCo5D5XMhiQo6Z5AwAOkTgkAyqDKOJcDMn4yWxdVbuqNbrNPozH_Evmzzem7HLTbrr8Sm9cVVSlabzKetOiNg5b9HSXZ2XqMo3H5MBi3piTnzsiq7vb5eTBnz3fTyfjmW850NaPEoZBaERkVaATCSoAqakMk8BSk6ScaYZWp5YpRJmAkVwrkyYolJGWR5KPyNmuW2-TwqRx7bICXRf_bunBxQ_ARmNuHZY6a_5dKBSVTPXO37msac3n3x_deyxDHop4OV_E68c5TPj6Jf7unu-8xSrGV9c3VwsGtJ8FUjBJ-ReXDnAS</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Yoon, J.S</creator><creator>Lee, M.K</creator><creator>Sung, S.H</creator><creator>Kim, Y.C</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20060201</creationdate><title>Neuroprotective 2-(2-Phenylethyl)chromones of Imperata cylindrica</title><author>Yoon, J.S ; Lee, M.K ; Sung, S.H ; Kim, Y.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f301t-9b2a47e59f84cb608406c167b4f1ebd32c2afcdf28aa6b0e63c8edba58e6f3963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>2-(phenylethyl)chromone</topic><topic>Adrenal Cortex - cytology</topic><topic>Adrenal Cortex - drug effects</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>chemical structure</topic><topic>Chromones - chemistry</topic><topic>Chromones - isolation & purification</topic><topic>Chromones - pharmacology</topic><topic>flavonoids</topic><topic>General pharmacology</topic><topic>Glutamic Acid - pharmacology</topic><topic>Imperata cylindrica</topic><topic>Korea</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>neurons</topic><topic>Neuroprotective Agents - chemistry</topic><topic>Neuroprotective Agents - isolation & purification</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>neuroprotective effect</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>Poaceae - chemistry</topic><topic>Rats</topic><topic>Rhizome</topic><topic>spectral analysis</topic><topic>traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, J.S</creatorcontrib><creatorcontrib>Lee, M.K</creatorcontrib><creatorcontrib>Sung, S.H</creatorcontrib><creatorcontrib>Kim, Y.C</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, J.S</au><au>Lee, M.K</au><au>Sung, S.H</au><au>Kim, Y.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotective 2-(2-Phenylethyl)chromones of Imperata cylindrica</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>69</volume><issue>2</issue><spage>290</spage><epage>291</epage><pages>290-291</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Bioactivity-guided fractionation of the methanolic extract of the rhizomes of Imperata cylindrica afforded a new compound, 5-hydroxy-2-(2-phenylethyl)chromone (1), together with three known compounds, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (2), flidersiachromone (3), and 5-hydroxy-2-styrylchromone (4). Among these four compounds, 1 and 2 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>16499335</pmid><doi>10.1021/np0503808</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2006-02, Vol.69 (2), p.290-291 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_pubmed_primary_16499335 |
| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | 2-(phenylethyl)chromone Adrenal Cortex - cytology Adrenal Cortex - drug effects Animals Biological and medical sciences Cells, Cultured chemical structure Chromones - chemistry Chromones - isolation & purification Chromones - pharmacology flavonoids General pharmacology Glutamic Acid - pharmacology Imperata cylindrica Korea Medical sciences medicinal plants neurons Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology neuroprotective effect Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Poaceae - chemistry Rats Rhizome spectral analysis traditional medicine |
| title | Neuroprotective 2-(2-Phenylethyl)chromones of Imperata cylindrica |
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