Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: Different effects on cytokines and apoptosis

A peptide (hCDR1) based on the sequence of the complementarity-determining region-1 of an anti-DNA autoantibody ameliorates clinical manifestations of lupus. We analyzed the beneficial effects of hCDR1 when given alone or in combination with dexamethasone, while comparing the mechanisms of action of...

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Bibliographic Details
Published in:Clinical Immunology 2006-05, Vol.119 (2), p.146-155
Main Authors: Sharabi, Amir, Haviv, Asher, Zinger, Heidy, Dayan, Molly, Mozes, Edna
Format: Article
Language:English
Subjects:
(NZBxNZW)F1 mice
Animals
Anti-Inflammatory Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Apoptosis - immunology
Autoantibodies - physiology
Biological and medical sciences
Complementarity Determining Regions - physiology
Cytokines
Cytokines - biosynthesis
Cytokines - metabolism
Dexamethasone
Dexamethasone - pharmacology
Fas Ligand Protein
Fas pathway
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunomodulation
Immunopathology
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - metabolism
Lupus Erythematosus, Systemic - pathology
Medical sciences
Membrane Glycoproteins - metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred NZB
Peptide Fragments - physiology
Peptides
Systemic lupus erythematosus
Tumor Necrosis Factors - metabolism
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