Absence of BRAF Gene Mutation in Non-Melanoma Skin Tumors

Basal cell carcinoma (BCC) is the most common skin cancer, and its incidence is increasing. It was proposed that the RAS oncogene significantly contributes to skin cancer development. Numerous BRAF mutations have been detected in melanoma biopsy specimens and cell lines. For the first time, in the p...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2006-05, Vol.5 (9), p.968-970
Main Authors: Libra, Massimo, Malaponte, Grazia, Bevelacqua, Valentina, Siciliano, Roberta, Castrogiovanni, Paola, Fulvi, Alberto, Micali, Giuseppe, Ligresti, Giovanni, Mazzarino, Maria C, Stivala, Franca, Travali, Salvatore, McCubrey, James A
Format: Article
Language:English
Subjects:
Binding
Biology
Biopsy
Bioscience
Calcium
Cancer
Carcinoma, Basal Cell - genetics
Carcinoma, Basal Cell - pathology
Cell
Cycle
DNA Mutational Analysis
Female
Humans
Landes
Male
Mutation
Organogenesis
Proteins
Proto-Oncogene Proteins B-raf - genetics
Skin Neoplasms - genetics
Skin Neoplasms - pathology
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Summary:Basal cell carcinoma (BCC) is the most common skin cancer, and its incidence is increasing. It was proposed that the RAS oncogene significantly contributes to skin cancer development. Numerous BRAF mutations have been detected in melanoma biopsy specimens and cell lines. For the first time, in the present study, tumor biopsy specimens from 78 patients with BCC were screened for BRAF mutation within exons 11 and 15. Our results indicate that the BRAF gene does not appear to be frequently mutated in non-melanoma skin tumors such as BCC. These data suggest that other gene alterations may cause tumor development.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.5.9.2724