Exhaled nitric oxide in single and repetitive prolonged exercise

• Published in: Journal of sports sciences 2006-11, Vol.24 (11), p.1157-1163
• Main Authors: Verges, S., Tonini, J., Flore, P., Favre-Juvin, A., Lévy, P., Wuyam, B.
• Format: Article
• Language: English
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; bronchial nitric oxide; chronic exercise; Endurance exercise; Exercise - physiology; Exhalation - physiology; Female; Fundamental and applied biological sciences. Psychology; Heart Rate - physiology; Humans; Male; Nitric Oxide - metabolism; Oxygen Consumption - physiology; Physical Endurance - physiology; Pulmonary Gas Exchange; Regression Analysis; single exercise; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
• ISSN: 0264-0414; 1466-447X
• DOI: 10.1080/02640410500457364

This study was performed to determine the influence of single and repetitive exercise on nitric oxide (NO) concentration in the lung. Exhaled NO concentration (FE NO ) was measured during a constant-flow exhalation manoeuvre (170 ml · s −1 , against a 10 cmH 2 O resistance) in healthy individuals (a) during and after a 100-min square-wave exercise of between 25 and 60% of maximal power output (n = 18) and (b) before and after five successive prolonged exercises (90 - 120 min, 75 - 85% of maximal heart rate) separated by 48 or 24 h (n = 8). The FE NO0.170 was decreased during and after the 100-min exercise test (mean± s [xbar] : 58.5 ± 3.7% and 76.7 ± 5.2% of resting value at 90 min of exercise and 15 min post-exercise, respectively; P  0.05). These results suggest that prolonged exercise induces a reduction in NO concentration within the lung that lasts for several minutes after the end of exercise. However, repetitive exercises (at least every 24 h) allow complete NO recovery from one session to another. The implication of such a decrease in NO availability within the lung remains to be clarified.