FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein

Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Abeta) accumulation, which is associated with Alzheimer disease, results in synaptic loss and impaired neurotransmission. Fragile X mental retardation protein (FMRP) is a cytoplasmic mRNA bindi...

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Bibliographic Details
Published in:PLoS biology 2007-03, Vol.5 (3), p.e52
Main Authors: Westmark, Cara J, Malter, James S
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyloid beta-Protein Precursor - genetics
Animals
Base Sequence
Behavior
Colleges & universities
Enzyme-Linked Immunosorbent Assay
Fragile X Mental Retardation Protein - genetics
Fragile X Mental Retardation Protein - physiology
Humans
Intellectual disabilities
Mental retardation
Mice
Mice, Inbred C57BL
Mice, Knockout
Molecular Sequence Data
Protein Biosynthesis - physiology
Proteins
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate - physiology
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Sequence Homology, Nucleic Acid
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