Exercise-induced suppression of acylated ghrelin in humans

• Published in: Journal of applied physiology (1985) 2007-06, Vol.102 (6), p.2165-2171
• Main Authors: Broom, D. R, Stensel, D. J, Bishop, N. C, Burns, S. F, Miyashita, M
• Format: Article
• Language: English
• Subjects: Acylation; Adult; Appetite - physiology; Biochemistry; Biological and medical sciences; Cells; Endocrine system; Exercise Test; Fundamental and applied biological sciences. Psychology; Ghrelin; Hormones; Humans; Male; Metabolism; Peptide Hormones - blood; Physical Endurance - physiology; Physical Exertion - physiology; Running - physiology
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00759.2006

School of Sport and Exercise Sciences, Loughborough University, Leicestershire, United Kingdom Submitted 8 July 2006 ; accepted in final form 6 March 2007 Ghrelin is an orexigenic hormone secreted from endocrine cells in the stomach and other tissues. Acylation of ghrelin is essential for appetite regulation. Vigorous exercise induces appetite suppression, but this does not appear to be related to suppressed concentrations of total ghrelin. This study examined the effect of exercise and feeding on plasma acylated ghrelin and appetite. Nine male subjects aged 19–25 yr participated in two, 9-h trials (exercise and control) in a random crossover design. Trials began at 0800 in the morning after an overnight fast. In the exercise trial, subjects ran for 60 min at 72% of maximum oxygen uptake between 0800 and 0900. After this, they rested for 8 h and consumed a test meal at 1100. In the control trial, subjects rested for 9 h and consumed a test meal at 1100. Area under the curve values for plasma acylated ghrelin concentration (assessed from venous blood samples) were lower over the first 3 h and the full 9 h of the exercise trial compared with the control trial: 317 ± 135 vs. 510 ± 186 pg·ml –1 ·3 h and 917 ± 342 vs. 1,401 ± 521 pg·ml –1 ·9 h (means ± SE) respectively ( P