Synapsin Phosphorylation by Src Tyrosine Kinase Enhances Src Activity in Synaptic Vesicles

Synapsins are synaptic vesicle-associated phosphoproteins implicated in the regulation of neurotransmitter release. Synapsin I is the major binding protein for the SH3 domain of the kinase c-Src in synaptic vesicles. Its binding leads to stimulation of synaptic vesicle-associated c-Src activity. We...

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Bibliographic Details
Published in:The Journal of biological chemistry 2007-05, Vol.282 (21), p.15754-15767
Main Authors: Onofri, Franco, Messa, Mirko, Matafora, Vittoria, Bonanno, Giambattista, Corradi, Anna, Bachi, Angela, Valtorta, Flavia, Benfenati, Fabio
Format: Article
Language:English
Subjects:
Animals
Mice
Mice, Knockout
Phosphorylation
Protein Binding - genetics
Protein Processing, Post-Translational - physiology
Proto-Oncogene Proteins c-fyn - metabolism
Signal Transduction - physiology
src Homology Domains - genetics
src-Family Kinases - metabolism
Synapsins - deficiency
Synapsins - metabolism
Synaptic Vesicles - enzymology
Synaptosomes - enzymology
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