Supercritical carbon dioxide: putting the fizz into biomaterials

This paper describes recent progress made in the use of high pressure or supercritical fluids to process polymers into three-dimensional tissue engineering scaffolds. Three current examples are highlighted: foaming of acrylates for use in cartilage tissue engineering; plasticization and encapsulatio...

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Bibliographic Details
Published in:Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences physical, and engineering sciences, 2006-01, Vol.364 (1838), p.249-261
Main Authors: Barry, John J.A, Silva, Marta M.C.G, Popov, Vladimir K, Shakesheff, Kevin M, Howdle, Steven M
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biomaterials
Carbon dioxide
Carbon Dioxide - chemistry
Chondrocytes
Chromatography, Supercritical Fluid - methods
Foams
Methacrylates
Molecular Conformation
Nanostructures - chemistry
Nanostructures - ultrastructure
Polyesters
Polymer Scaffold Foam
Polymers
Polymers - chemistry
Porosity
Pressure
Scaffolds
Supercritical Carbon Dioxide
Tissue engineering
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Summary:This paper describes recent progress made in the use of high pressure or supercritical fluids to process polymers into three-dimensional tissue engineering scaffolds. Three current examples are highlighted: foaming of acrylates for use in cartilage tissue engineering; plasticization and encapsulation of bioactive species into biodegradable polyesters for bone tissue engineering; and a novel laser sintering process used to fabricate three-dimensional biodegradable polyester structures from particles prepared via a supercritical route.
ISSN:1364-503X
1471-2962
DOI:10.1098/rsta.2005.1687