Cellular and organismal ageing: Role of the p53 tumor suppressor protein in the induction of transient and terminal senescence

In recent years, an impact of the p53 tumor suppressor protein in the processes of cellular and organismal ageing became evident. First hints were found in model organisms like Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster where a clear connection between ageing pheno...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular biochemistry 2007-08, Vol.101 (6), p.1355-1369
Main Authors: Schmid, Gerald, Kramer, Matthias P., Maurer, Margarita, Wandl, Stefanie, Węsierska-Gądek, Józefa
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Carrier Proteins - metabolism
CDK inhibitors
cell cycle
cell-cycle arrest
Cellular Senescence - physiology
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Enzyme Activation
HIPK2
Humans
Mdm2
Neoplasm Proteins - metabolism
Neoplasms - genetics
Neoplasms - metabolism
Nuclear Proteins - metabolism
p53 isoforms
p53 stability
p53 ubiquitylation
PML
Promyelocytic Leukemia Protein
Protein Isoforms - genetics
Protein Isoforms - metabolism
Protein-Serine-Threonine Kinases - metabolism
Proto-Oncogene Proteins c-mdm2 - metabolism
Transcription Factors - metabolism
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Proteins - metabolism
Ubiquitin-Protein Ligases - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!