Effect of Propranolol on Naming in Chronic Broca's Aphasia with Anomia

Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate...

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Bibliographic Details
Published in:Neurocase 2007-08, Vol.13 (4), p.256-259
Main Authors: Beversdorf, David Q., Sharma, Umesh K., Phillips, Nicole N., Notestine, Margaret A., Slivka, Andrew P., Friedman, Norman M., Schneider, Sandra L., Nagaraja, Haikady N., Hillier, Ashleigh
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Aged
Analysis of Variance
Anomia - drug therapy
Anomia - etiology
Anomia - physiopathology
aphasia
Aphasia, Broca - complications
Aphasia, Broca - drug therapy
Aphasia, Broca - etiology
Association Learning - drug effects
Humans
language
Language Tests
Middle Aged
Names
Neuropsychological Tests
norepinephrine
propranolol
Propranolol - therapeutic use
Reaction Time - drug effects
stroke
Stroke - complications
β-Adrenergic
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Summary:Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a given visual stimulus in a naming task. Therefore, we tested naming in a pilot study of chronic Broca's aphasia patients with anomia after propranolol and after placebo in a double-blinded crossover manner. Naming was better after propranolol than after placebo, suggesting a potential benefit from propranolol in chronic Broca's aphasia with anomia. Larger follow-up studies are necessary to further investigate this effect.
ISSN:1355-4794
1465-3656
DOI:10.1080/13554790701595471