A Peptide That Ameliorates Lupus Up-Regulates the Diminished Expression of Early Growth Response Factors 2 and 3

Expansion of autoreactive T cells and their resistance to anergy was demonstrated in systemic lupus erythematosus (SLE). A pair of transcription factors, early growth response 2 (Egr-2) and 3 (Egr-3), are negative regulators of T cell activation that were shown to be important in anergy. A peptide (...

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Bibliographic Details
Published in:	The Journal of immunology (1950) 2008-02, Vol.180 (3), p.1584-1591
Main Authors:	Sela, Uri, Dayan, Molly, Hershkoviz, Rami, Lider, Ofer, Mozes, Edna
Format:	Article
Language:	English
Subjects:	Animals Antibodies, Monoclonal - pharmacology Clonal Anergy - drug effects Early Growth Response Protein 2 - antagonists & inhibitors Early Growth Response Protein 2 - genetics Early Growth Response Protein 2 - metabolism Early Growth Response Protein 3 - antagonists & inhibitors Early Growth Response Protein 3 - genetics Early Growth Response Protein 3 - metabolism Humans Interferon-gamma - metabolism Interleukin-2 - pharmacology Lupus Erythematosus, Systemic - immunology Mice Mice, Inbred Strains Peptide Fragments - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-cbl - metabolism Recombinant Proteins - pharmacology RNA, Messenger - metabolism T-Lymphocytes - drug effects T-Lymphocytes - immunology Transforming Growth Factor beta1 - metabolism Up-Regulation
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