Detection of stellate distortions in mammograms

• Published in: IEEE transactions on medical imaging 1996-10, Vol.15 (5), p.611-619
• Main Authors: Karssemeijer, N., te Brake, G.M.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Breast cancer; Cancer detection; Computer errors; Genital system. Mammary gland; Hospitals; Image generation; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Noise generators; Pixel; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiology; Statistical analysis; Tellurium
• ISSN: 0278-0062; 1558-254X
• DOI: 10.1109/42.538938

Malignant densities in mammograms have an irregular appearance and frequently are surrounded by a radiating pattern of linear spicules. In this paper a method is described to detect such stellate patterns. This method is based on statistical analysis of a map of pixel orientations. If an increase of pixels pointing to a region is found, this region is marked as suspicious, especially if such an increase is found in many directions. Orientations of the image intensity map are determined at each pixel using a multiscale approach. At a given scale, accurate line-based orientation estimates are obtained from the output of three-directional, second-order, Gaussian derivative operators. The orientation at the scale at which these operators have maximum response is selected. If a line-like structure is present at a given site, this method provides an estimate of the orientation of this structure, whereas in other cases the image noise will generate a random orientation. The pixel orientation map is used to construct two operators which are sensitive to radial patterns of straight lines. Combination of the output of these operators using a classifier allows for detection of stellate patterns. Different classification methods have been compared and results obtained on a common database are presented. Around 90% of the malignant cases were detected at rate of one false positive (FP) per image.