Reappraisal of H2S/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling

1 Indiana University School of Medicine-South Bend, South Bend; and 2 Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana Submitted 11 January 2008 ; accepted in final form 15 April 2008 Hydrogen sulfide (H 2 S) is rapidly emerging as a biologically significant signaling...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2008-06, Vol.294 (6), p.R1930-R1937
Main Authors: Whitfield, Nathan L, Kreimier, Edward L, Verdial, Francys C, Skovgaard, Nini, Olson, Kenneth R
Format: Article
Language:English
Subjects:
Animals
Biomarkers - blood
Cattle
Hydrogen Sulfide - blood
Ischemic Preconditioning, Myocardial
Oncorhynchus mykiss
Petromyzon
Polarography
Rats
Rats, Inbred Strains
Signal Transduction - physiology
Sus scrofa
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Summary:1 Indiana University School of Medicine-South Bend, South Bend; and 2 Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana Submitted 11 January 2008 ; accepted in final form 15 April 2008 Hydrogen sulfide (H 2 S) is rapidly emerging as a biologically significant signaling molecule. Studies published before 2000 report low or undetectable H 2 S (usually as total sulfide) levels in blood or plasma, whereas recent work has reported sulfide concentrations between 10 and 300 µM, suggesting it acts as a circulating signal. In the first series of experiments, we used a recently developed polarographic sensor to measure the baseline level of endogenous H 2 S gas and turnover of exogenous H 2 S gas in real time in blood from numerous animals, including lamprey, trout, mouse, rat, pig, and cow. We found that, contrary to recent reports, H 2 S gas was essentially undetectable (
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.00025.2008