Frequency distribution of the nanoparticle magnetization in the presence of a static as well as a harmonic magnetic field

We explore the properties of the signal from magnetic nanoparticles. The nanoparticle signal has been used to generate images in magnetic particle imaging (MPI). MPI promises to be one of the most sensitive methods of imaging small numbers magnetic nanoparticles and therefore shows promise for molec...

Full description

Saved in:
Bibliographic Details
Published in:Medical physics (Lancaster) 2008-05, Vol.35 (5), p.1988-1994
Main Authors: Weaver, John B., Rauwerdink, Adam M., Sullivan, Charles R., Baker, Ian
Format: Article
Language:English
Subjects:
Algorithms
biomedical optical imaging
Coils
Electromagnetic Fields
Equipment Design
Ferric Compounds - chemistry
Fourier Analysis
Image Processing, Computer-Assisted
Iron
Magnetic field measurements
Magnetic fields
Magnetic hysteresis
Magnetic nanoparticles
magnetic particles
Magnetic Resonance Imaging
Magnetics
Medical imaging
Metal Nanoparticles - chemistry
Models, Statistical
nanobiotechnology
nanoparticles
Nanoparticles - chemistry
Nanostructures - chemistry
Nanotechnologies‐applications
Nanotechnology - methods
Radiation Therapy Physics
Second harmonic generation
Temperature
Visual imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We explore the properties of the signal from magnetic nanoparticles. The nanoparticle signal has been used to generate images in magnetic particle imaging (MPI). MPI promises to be one of the most sensitive methods of imaging small numbers magnetic nanoparticles and therefore shows promise for molecular imaging. The nanoparticle signal is generated with a pure sinusoidal magnetic field that repeatedly saturates the nanoparticles creating harmonics in the induced magnetization that are easily isolated from the driving field. Signal from a selected position is isolated using a static magnetic field to completely saturate all of the particles outside a voxel enabling an image to be formed voxel by voxel. The signal produced by the magnetization of the nanoparticles contains only odd harmonics. However, it is demonstrated experimentally that with the addition of a static magnetic field bias even harmonics are introduced which increase the total signal significantly. Further, the distribution of signal among the harmonics depends on the static bias field so that information might be used to localize the nanoparticle distribution. Finally, the field required to completely saturate nanoparticles can be quite large and theory predicts that the field required is determined by the smallest nanoparticles in the sample.
ISSN:0094-2405
2473-4209
DOI:10.1118/1.2903449