Effects of asimilobine on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells

The effects of asimilobine, an aporphine isoquinoline alkaloid, on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells were investigated. Asimilobine at concentration ranges of 0.05-0.2 microM showed a significant inhibition of intracellular dopamine levels for 24 h in a concentratio...

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Bibliographic Details
Published in:Journal of asian natural products research 2008-07, Vol.10 (7-8), p.747
Main Authors: Jin, Chun-Mei, Lee, Jae-Joon, Kim, Young-Kyoon, Ryu, Shi-Yong, Lim, Sung-Cil, Hwang, Bang-Yeon, Lee, Chong-Kil, Lee, Myung-Koo
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Aporphines - chemistry
Aporphines - pharmacology
Aromatic-L-Amino-Acid Decarboxylases - metabolism
Dopamine - biosynthesis
Dopamine Agents - chemistry
Dopamine Agents - pharmacology
Gene Expression Regulation, Enzymologic
Levodopa - pharmacology
Molecular Structure
PC12 Cells
Rats
RNA, Messenger - genetics
RNA, Messenger - metabolism
Tyrosine 3-Monooxygenase - metabolism
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